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夏建川

【内科 副主任医师】

详细介绍

1997年于哈尔滨医科大学获医学博士学位。1998-2000年在中山医科大学做博士后研究工作,从事鼻咽癌易感基因的定位研究;2000-2003年在美国哈佛大学Dana-Farber肿瘤研究所从事肿瘤遗传学和肿瘤疫苗的研究。现任中山大学附属肿瘤医院生物治疗研究中心副主任,国家药品食品监督管理局(SFDA)药物评审咨询专家,广东省委高干保健专家,生物治疗研究中心博士导师。主要研究方向为肿瘤遗传学和肿瘤生物治疗。

荣誉成就 1.《胃癌的细胞和分子遗传学研究》 黑龙江省科学技术进步二等奖,1998年度,排名第第三 2.《胃癌的细胞和分子遗传学研究》 黑龙江省教委科技进步奖一等奖,1998年度,排名第第三 获得一项国家发明专利(专利号:ZL 03146933.7)“一种分离纯化人肿瘤细胞的方法”。

社会任职 中华医学会(CMA)会员(2004-至今) 中国抗癌协会(CACA)会员(2003-至今) 中国抗癌学会肿瘤生物治疗临床应用专业委员会会员(2006-至今) 中国抗癌学会广东省生物治疗专业委员会员(2006-至今) 中国细胞生物专业学会会员(2006-至今) 中国免疫学会会员(2006-至今) 中国肿瘤生物治疗临床应用专业委员会常委(2006-至今) 中国抗癌协会广东省生物治疗专业委员会常委(2005-至今) 中国抗癌协会介入微创治疗专业委员会常委(2006-至今) 中国细胞生物学会广东省免疫与生物治疗专业委员会主任委员(2005-至今) 中国免疫学会免疫与生物治疗专业委员会委员(2006-至今) 《癌症》杂志责任编委(2003-至今) 《Cancer letter》杂志编委(2006-至今) 《WJG》杂志编委 (2005-至今)

论文发表 1. Sun JC, Pan K, Chen MS, Wang QJ, Wang H, Ma HQ, Li YQ, Liang XT, Li JJ, Zhao JJ, Chen YB, Pang XH, Liu WL, Cao Y, Guan XY, Lian QZ, Xia JC. Dendritic cells-mediated CTLs targeting hepatocellular carcinoma stem cells. Cancer Biol Ther. 2010 Aug 22;10(4). 2. Ma H, Weng D, Chen Y, Huang W, Pan K, Wang H, Sun J, Wang Q, Zhou Z, Wang H, Xia J. Extensive analysis of D7S486 in primary gastric cancer supports TESTIN as a candidate tumor suppressor gene. Mol Cancer. 2010 Jul 13;9(1):190. 3. Ma H, Liang X, Chen Y, Pan K, Sun J, Wang H, Wang Q, Li Y, Zhao J, Li J, Chen M, Xia J. Decreased expression of BATF2 is associated with a poor prognosis in hepatocellular carcinoma. Int J Cancer. 2010 Apr 19. 4. Ma H, Zhang Y, Wang Q, Li Y, He J, Wang H, Sun J, Pan K, Chen M, Xia J. Therapeutic safety and effects of adjuvant autologous RetroNectin activated killer cell immunotherapy for patients with primary hepatocellular carcinoma after radiofrequency ablation. Cancer Biol Ther. 2010 Jun 6;9(11). 5. Zhang H, Ma H, Wang Q, Chen M, Weng D, Wang H, Zhou J, Li Y, Sun J, Chen Y, Liang X, Zhao J, Pan K, Wang H, Xia J. Analysis of loss of heterozygosity on chromosome 4q in hepatocellular carcinoma using high-throughput SNP array. Oncol Rep. 2010 Feb;23(2):445-55. 6. Ma HQ, Liang XT, Zhao JJ, Wang H, Sun JC, Chen YB, Pan K, Xia JC. Decreased expression of Neurensin-2 correlates with poor prognosis in hepatocellular carcinoma. World J Gastroenterol. 2009 Oct 14;15(38):4844-8. 7. Zhou J, Weng D, Zhou F, Pan K, Song H, Wang Q, Wang H, Wang H, Li Y, Huang L, Zhang H, Huang W, Xia JC. Patient-derived renal cell carcinoma cells fused with allogeneic dendritic cells elicit anti-tumor activity: in vitro results and clinical responses. Cancer Immunology Immunotherapy, 2009 Oct;58(10):1587-1597. 8. Pan K, Wang H, Liu W, Zhang H, Zhou J, Li J, Weng D, Huang W, Sun J, Liang X, Xia JC. The pivotal role of p38 and NF-κB signal pathways in the maturation of human monocyte-derived dendritic cells stimulated by streptococcal agent OK-432. Immunobiology, 2009, 214(5):350-358. 9. Zhang HK, Pan K, Wang H, Weng DS, Song HF, Zhou J, Huang W, Li JJ, Chen MS, Xia JC. Decreased Expression of Ing2 Gene and Its Clinicopathological Significance in Hepatocellular Carcinoma. Cancer Lett, 2008, 261(2): 183-192. 10. Weng DS, Zhou J, Zhou QM, Zhao M, Wang QJ, Huang LX, Li YQ, Chen SP, Wu PH, Xia JC. Minimally Invasive Treatment Combined with Cytokine-Induced Killer Cells Therapy Lower the Short-Term Recurrence Rates of Hepatocellular Carcinomas. J Immunother, 2008, 31(1): 63-71. 11. Wang H, Pan K, Zhang HK, Weng DS, Zhou J, Li JJ, Huang W, Song HF, Chen MS, Xia JC. Increased Polycomb-Group Oncogene Bmi-1 Expression Correlates with Poor Prognosis in Hepatocellular Carcinoma. J Cancer Res Clin Oncol. 2008, 134(5): 535-541. 12. Pan K, Wang H, Chen MS, Zhang HK, Weng DS, Zhou J, Huang W, Li JJ, Song HF, Xia JC. Expression and prognosis role of indoleamine 2,3-dioxygenase in hepatocellular carcinoma. J Cancer Res Clin Oncol. 2008, 134(11):1247-1253 13. Li JJ, Xu GL, Gu MF, Luo GY, Rong Z, Wu PH, Xia JC. Complications of high intensity focused ultrasound in patients with recurrent and metastatic abdominal tumors. World J Gastroenterol. 2007, 13(19):2747-2751. 14. Liu JY, Wu Y, Zhang XS, Yang JL, Li HL, Mao YQ, Wang Y, Cheng X, Li YQ, Xia JC, Masucci M, Zeng YX. Single administration of low dose cyclophosphamide augments the antitumor effect of dendritic cell vaccine. Cancer Immunol Immunother. 2007, 56(10):1597-1604. 15. Weng DS, Li JT, Mai SJ, Pan ZZ, Feng BJ, Feng QS, Huang LX, Wang QJ, Li YQ, Yu XJ, Chen SP, He J, Xia JC. Identification of a new target region on the long arm of chromosome 7 in gastric carcinoma by loss of heterozygosity. World J Gastroenterol. 2006, 12(15):2437-2440. 16. Xia JC, Weng DS, Li JT, Qin HD, Mai SJ, Feng BJ, Fan Q, Feng QS, Huang LX, Yu XJ, Pan ZZ, Li YQ, Wang QJ, Zhan YQ, Chen SP, He J, Huang WL, Wu PH, Zeng YX. Loss of heterozygosity analysis of a candidate gastric carcinoma tumor suppressor locus at 7q31. Cancer Genet Cytogenet. 2006, 166(2):166-172. 17. Liu JY, Zhang XS, Ding Y, Peng RQ, Cheng X, Zhang NH, Xia JC, Zeng YX. The changes of CD4+CD25+/CD4+ proportion in spleen of tumor-bearing BALB/c mice. J Transl Med. 2005, 28;3(1):5. 18. Zhang XS, Wang HH, Hu LF, Li A, Zhang RH, Mai HQ, Xia JC, Chen LZ, Zeng YX. V-val subtype of Epstein-Barr virus nuclear antigen 1 preferentially exists in biopsies of nasopharyngeal carcinoma. Cancer Lett. 2004, 211(1):11-18 19. Tanaka Y, Koido S, Xia JC, Ohana M, Liu C, Cote GM, Sawyer DB, Calderwood S, Gong J. Development of Antigen-Specific CD8+ Cytotoxic T Lymphocytes in MHC Class I-Deficient Mice through CD4 to CD8 Conversion. J Immunol, 2004, 172: 7848-7858. 20. Xia JC, Tanaka Y, Koido S, Liu C, Mukherjee P, Gendler SJ, Gong J Prevention of spontaneous breast carcinoma by prophylactic vaccination with dendritic/tumor fusion cells. J Immunol, 2003, 170 (4):1980-1986. 21. Chen D, Xia JC, Tanaka Y, Chen H, Koido S, Wernet O, Mukherjee P, Gendler SJ, Kufe D, Gong J. Immunotherapy of spontaneous mammary carcinoma with fusions of dendritic cell and mucin 1-positive carcinoma cells. Immunology 2003, 109:300-307.